Symmetric signaling by an asymmetric 1 erythropoietin: 2 erythropoietin receptor complex.

New pathogenic mechanisms induced by germline erythropoietin receptor mutations in primary erythrocytosis

Primary familial and congenital polycythemia is characterized by erythropoietin hypersensitivity of erythroid progenitors due to germline nonsense or frameshift mutations in the erythropoietin receptor gene. All mutations so far described lead to the truncation of the C-terminal receptor sequence that contains negative regulatory domains. Their removal is presented as sufficient to cause the er...

Protective effects of erythropoietin against cuprizone-induced oxidative stress and demyelination in the mouse corpus callosum

Objective(s): Increasing evidence in both experimental and clinical studies suggests that oxidative stress plays a major role in the pathogenesis of multiple sclerosis. The aim of the present work is to investigate the protective effects of erythropoietin against cuprizone-induced oxidative stress. Materials and Methods: Adult male C57BL/6J mice were fed a chow containing 0.2 % cuprizone for 6 ...

A cordial affair - erythropoietin and cardioprotection.

Hypoxia and erythropoietin (EPO) were a couple from the very beginning. Hypoxia induces the production of EPO, which became the paradigm for oxygen-regulated gene expression [1]. Dissecting EPO gene regulation has lead to the discovery of the transcription factor complex hypoxia inducible factor-1 (HIF-1), the widespread “master regulator of O2 homeostasis” in the tissue, and the identification...

Macrophages as novel target cells for erythropoietin.

BACKGROUND Our original demonstration of immunomodulatory effects of erythropoietin in multiple myeloma led us to the search for the cells in the immune system that are direct targets for erythropoietin. The finding that lymphocytes do not express erythropoietin receptors led to the hypothesis that other cells act as direct targets and thus mediate the effects of erythropoietin. The finding tha...

Development of Radiolabeled Recombinant Erythropoietin for Receptor Studies